Development and Feasibility Testing of a Cross-Ancestry Polygenic Risk Score Pipeline for Ischemic Stroke in an Indonesian Population

Abstract

Ischemic stroke susceptibility is significantly influenced by polygenic factors, yet current Polygenic Risk Scores (PRS) are produced from predominantly European Genome-Wide Association Studies (GWAS). Using European ancestry genetic weights to non-European cohorts often reduces prediction accuracy. Southeast Asia, specifically Indonesia, remains very underrepresented in genomic consortia, leaving a huge gap in determining the most effective models for risk stratification. To address this, the study develops a standardized bioinformatics cross-ancestry PRS pipeline and evaluates its computational feasibility through a matched pilot study in an Indonesian cohort