T cell epitope prediction of cancer antigens restricted by HLA A*24:07

Abstract

T cells are the primary effector cells of tumor immunity. T cells recognized peptides derived from tumor antigens wich is presented as a complex with HLA (histocompatibility leukocyte antigen - HLA) on the surface of target cells. HLA-A*24:07 is the major HLA alleles in Indonesia. HLA A*24:07 is considered unique and not a member of the HLA A*24 supertype, which is represented by HLA A*24:02. The two molecules, A*24:02 and A*24:07, share high homology except for one amino acid residue number 70. Residue number 70 in A*24:02 is H and in A*24:07 is Q. This residue happens to be in the peptide binding groove of the HLA allele, and affecting at least 3 out of 6 peptide binding pockets. HLA-A*24:07 is a less characterized allele, and at the moment, there is only one T-cell epitopes reported to be restricted by this HLA allele (IEDB website). The paper will present the peptide binding motif of HLA A*24:07, the benchmark of online T cell epitope prediction server, and the use of prediction server to predict peptide derived from cancer antigens that will bind to HLA A*24:07