Characterization of meso-Dihydroguaiaretic acid (MDGA) derivative as an anti-inflammatory agent against neutrophilic inflammation

Abstract

Inflammation is a crucial part of the immune response, involving neutrophils, the predominant white blood cells, in combating pathogens. Their recruitment is regulated during inflammation, which can lead to conditions like autoimmune diseases and cancer. This study aims to explore meso- Dihydroguaiaretic acid (MDGA) derivatives, particularly MZ47, as potential therapeutic options for neutrophil-induced inflammatory disorders. MZ47 demonstrates anti-inflammatory properties through interference with neutrophil activation, modulation of signalling pathways, direct inhibition of elastase activity, and antioxidant properties. It also exhibits inhibitory effects on reactive oxygen species (ROS) production and surface markers crucial for neutrophil function. The research findings may contribute to the advancement of MDGA derivatives as promising therapies for inflammatory diseases. By unravelling insights into their mechanisms of action, this study lays a foundation for further clinical exploration and development.