Evaluation of Delayed and Reversible Toxicity of Repeated Fennel (Foeniculum vulgare) Extract Administration in Mice

Abstract

This subchronic toxicity study assessed the delayed toxicity and reversibility of fennel extract in male and female mice. To ascertain any delayed toxicity and potential for recovery, a separate satellite group received oral doses of fennel extract at a dose of 1000 mg/kg/day of body weight for a duration of 90 days, followed by 28-days with no treatment. There were no abnormalities observed in the satellite group’s weight and biochemical parameters when compared to the control group. The findings indicate that fennel extract at a dose of 1000 mg/kg/day of body weight did not cause delayed oral subchronic toxicity in both male and female mice.