Please use this identifier to cite or link to this item: http://repository.i3l.ac.id/jspui/handle/123456789/917
Title: Investigation of Atopic Dermatititis-Related Gene Expression Levels of TNF-α- & IFN-γ-Induced HaCaT Treated with Calophyllum inophyllum Ethanol-Immiscible Exctract (EIE)
Authors: Hutabarat, Sarah Stefania
Keywords: Calophyllum inophyllum
tamanu oil
atopic dermatitis
gene expression
ethanol-immiscible extract
HaCaT
Issue Date: 12-Jun-2023
Publisher: Indonesia International Institute for Life Sciences
Series/Report no.: BM 23-007;T202306118
Abstract: Atopic dermatitis (AD) is a multifactorial chronic relapsing inflammatory skin disease characterized by flares of pruritic lesions, rashes and lichenification. Skin barrier and immune barrier dysfunction, grouped with genetic predisposition all contribute to the development of AD. Available medications with the purpose of mitigating symptoms and exacerbations provide surface-level therapeutic effects, and can lead to various undesirable side effects such as atrophy, stretch marks, and rosacea. Therefore current studies in this field of research have aimed to create novel drugs using natural products to treat AD that will yield effective results without the unwanted side effects. This study investigates the effects of C.inophyllum ethanol-immiscible extract (EIE) on major AD-related inflammatory genes IL-33, IL-25, TSLP, TARC, MDC, AND CTACK and skin barrier genes FLG and IVL in TNF-α and IFN-γ-induced HaCaT, in which EIE was shown to decrease the expression of IL-33, TLSP, MDC, and increase the expression of FLG and IVL. Thus, there is potential for tamanu oil as a therapy for AD as it has shown to exert anti-inflammation and skin barrier repair effects. Further studies may be done to confirm the effect of EIE on IL-25, TARC, and CTACK.
URI: http://repository.i3l.ac.id/jspui/handle/123456789/917
Appears in Collections:Biomedicine

Files in This Item:
File Description SizeFormat 
Abstract.pdfAbstract92.62 kBAdobe PDFView/Open
BM 23-007_Sarah Stefania Hutabarat.pdf
  Restricted Access
Full Text6.1 MBAdobe PDFView/Open Request a copy
Chapter 1.pdfChapter 1102.96 kBAdobe PDFView/Open
Cover.pdfCover131.59 kBAdobe PDFView/Open
References.pdfReferences185.15 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.