Please use this identifier to cite or link to this item:
Title: In vivo Pilot Study of Moisturizer Evaluation and Correlation between Ceramides Gene Expression Towards Trans Epidermal Water Loss (TEWL) in Skin Barrier
Authors: Bunardi, Chyntia Sherlyn
Keywords: Skin barrier
Transepidermal water loss
Tape striping
Issue Date: 12-Jun-2022
Publisher: Indonesia International Institute for Life Sciences
Series/Report no.: T202207026;BM 22-024
Abstract: Stratum corneum (SC) is the outermost layer of the skin surrounded by the lipid matrix and forms a multilamellar barrier for the skin. The main function of this layer is to prevent the permeation of external molecules into the epidermal and dermal layers and prevent excessive water loss from the skin (van Smeden & Bouwstra, n.d.). As the lamellar barrier's major lipid component, ceramides are crucial for the skin barrier function. Changes in ceramide profile are highly associated with barrier function impairment and correlated with trans epidermal water loss (TEWL), representing the water-holding ability of the skin barrier. Moisturizer efficiency in improving the barrier function was evaluated by TEWL measurement on seven subjects with three-time point measurements within four weeks (week 0, week 2, and week 4). Daily moisturizer application on most issues treated side of forearms led to the decrease of TEWL in the following measurement week compared to TEWL of the untreated forearms in which most subjects had the TEWL increased. This improvement might result from the active ingredients contained in the tested moisturizer product. However, the moisturizer's effectiveness was different in every subject, indicated by the variety of the TEWL results. Furthermore, the moisturizer composition might not be suitable for several subjects, which leads to disruption of barrier lipid composition and TEWL increase.
Appears in Collections:Biomedicine

Files in This Item:
File Description SizeFormat 
Chapter 1.pdfChapter 1156.95 kBAdobe PDFView/Open
Cover.pdfCover133.31 kBAdobe PDFView/Open
References.pdfReferences2.17 MBAdobe PDFView/Open
Abstract.pdfAbstract137.89 kBAdobe PDFView/Open
BM 22-024 Chyntia Sherlyn Bunardi.pdf
  Restricted Access
Full Text8.28 MBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.