http://http://repository.i3l.ac.id:80/handle/123456789/292 EP I3L's Student Report 2026-04-21T17:22:39Z http://http://repository.i3l.ac.id:80/handle/123456789/1273 Title: Exploring Polygenic Risk Score Calculation Pipelines Using Linux Command Line Interface Authors: Austin, Felicia Abstract: Polygenic risk scores (PRS) has become one of the most marketable research topics as medicine focused more into personalized healthcare. By using PRS, an individual's gene can guide both the patient and the healthcare professionals in making decisions regarding themself. As such, many different workflows and tools have been developed over the years in an effort to make PRS calculation easier, while still maintaining a good, proper result. Such tools include plink2, prspipe, and PRSice-2. Although those tools have their own documentation, an adaptation to use them with real life data has its own challenges. Many of which were due to data limitation, which eliminates the possibility of it being used in this specific case such as in the case of prspipe and PRSice-2. Meanwhile, plink2 as the most promising tool was also limited due to the small amount of sample which causes a skewed result. Therefore, this report can only be used as a proof of exploration towards the various workflows with limited conclusion. 2025-01-31T00:00:00Z http://http://repository.i3l.ac.id:80/handle/123456789/1272 Title: The Role of lncRNA XIST in Cancer: An In-Silico Approach Authors: Aminuddin, Mohamad Zafran Abstract: The lncRNA XIST was identified to play a core role in regulating gene expression and cancer development. XIST is known to be an X-chromosome inactivation (XCI) which silences one of the X-chromosomes. The current study is thus an in silico investigation of XIST expression status and associated genes in some types of cancer. Computational tools, including GEPIA2, UALCAN, cBioPortal, UCSC Xena, KMplotter, StringDB, Metacore, and IPA were used to make a systematic analysis of the XIST expression, gender-based comparisons, and association studies with proteins linked to XIST. Differential expression analysis, survival analysis, and pathway enrichment studies will be performed to validate findings and identify potential therapeutic targets. This study provides important insights based on in-silico analysis, experimental validation is crucial to confirm the findings and better understand the underlying biological mechanisms of XIST in colon adenocarcinoma (COAD). These findings emphasize the subtle role of XIST in COAD and suggest further research to understand its impact on cancer biology and possibly its role as a biomarker. 2025-01-31T00:00:00Z http://http://repository.i3l.ac.id:80/handle/123456789/1242 Title: Analyzing Rheological Parameters of Soy Lecithin and Its Impact on Biscuit Production Authors: Salam, Christabel Queentha Abstract: The internship tasks assigned by the Quality Control department in PT Mayora Indah Tbk of the biscuit division was divided into different sections of the department: QC-PM (Quality Control Packaging Material), QC-RM (Quality Control Raw Materials), QC Microbiology Lab (Quality Control Microbiology Laboratory), and QC ChemPhys Lab (Quality Control Chemistry-Physical Laboratory). These tasks incorporate the main activities done in the department, which were the quality inspection of supplies or materials to the final products whether they have met the company’s standard or not. As such, the inspections were done visually or physically in the incoming supplies section (QC-PM and QC RM) and laboratory analysis in the Quality Control Laboratory section. 2025-01-31T00:00:00Z http://http://repository.i3l.ac.id:80/handle/123456789/1241 Title: ProbiYo Kefir Milk Authors: Yong, Kenzie Andrew Abstract: ProbiYo Kefir Milk addresses the increasing prevalence of digestive health issues in Indonesia, driven by processed foods and limited dietary diversity. Current market options, such as kombucha and yogurt, are either expensive or lack the diverse probiotics needed for optimal gut health. ProbiYo fills this gap with an affordable, flavorful, and probiotic-rich beverage that caters to health-conscious individuals and those with lactose sensitivity. Through comprehensive internal and external analyses, ProbiYo has identified significant opportunities in Indonesia's health beverage market. External factors such as rising disposable incomes and growing health awareness align with the company's goals, while internal strengths like high-quality kefir grains, locally sourced milk, and advanced fermentation techniques ensure superior product quality. ProbiYo is based in Harapan Indah, Bekasi Barat, and operates as a sole proprietorship, reflecting its commitment to sustainability, innovation, and community support. ProbiYo targets urban, health-conscious consumers aged 25–45 and individuals experiencing digestive issues or lactose intolerance. This market is increasingly motivated by wellness trends and probiotic-rich nutrition. The company plans to reach its audience through a multi-channel marketing strategy that leverages e-commerce platforms like Shopee and Instagram, supported by educational campaigns and collaborations with fitness centers and health influencers. Led by a team of biotechnology and business experts, ProbiYo focuses on efficient operations and sustainable practices to ensure scalable growth. Financial projections demonstrate strong viability, with a five-year ROI of 44% and break-even expected within two years. The company seeks Rp 12.4 million in initial funding to cover equipment, production, and marketing expenses. By combining affordability, innovation, and sustainability, ProbiYo Kefir Milk aims to establish itself as Indonesia’s leading probiotic beverage brand while promoting public health and supporting local farmers. 2025-01-31T00:00:00Z